Following injuries of nerve cells due to direct trauma or slow degenerative processes, the content of the cell is released to the surrounding compartment allowing quantitative determinations of the axonal proteins. Increased levels of neurofilament light has been found in various degenerative diseases such as Amyotrophic lateral sclerosis, Alzheimers disease, Multiple sclerosis and in animal models such as chronic experimental autoimmune encephalomyelitis. Product inquiries.